Rifampicin (Rifampin)

Rifadin, Rimactane, Rifampin

Antimycobacterial • Rifamycin antibiotic

Hepatotoxic

Half-life

3-4 hours

Protein Binding

80%

Metabolized By

CYP3A4

External

Inhibits bacterial DNA-dependent RNA polymerase; one of the most potent CYP enzyme inducers known

Drug Class

Antimycobacterial

Subclass

Rifamycin antibiotic

RifadinRimactaneRifampin

Half-life

3-4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

80%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses