Simvastatin

Zocor

Statin • HMG-CoA reductase inhibitor

Hepatotoxic

Half-life

2-3 hours

Protein Binding

95%

Metabolized By

CYP3A4

External

Prodrug converted to active form that inhibits HMG-CoA reductase

Drug Class

Statin

Subclass

HMG-CoA reductase inhibitor

Zocor

Half-life

2-3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

95%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses