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  3. /Acetaminophen (Paracetamol)

Acetaminophen (Paracetamol)

Tylenol, Paracetamol, Panadol, Calpol, Little Fevers, Bactimicina, Pamprin Max Formula, Pamprin Multi-Symptom, Pamprin Cramp Formula, Percogesic Reformulated Jan 2011, Premsyn PMS, Panadol PM, CounterAct Pain, Capacet, Nortemp, Acetadryl, Ringl, Pharbetol, Arthriten Inflammatory Pain, Backaid, Cetafen, Exaprin, Backaid IPF, Lortab, Primlev, Verdrocet, Excedrin Mild Headache, Excedrin PM Triple Action, Ninjacof A, Vanatol, Fioricet, Sed-Max, Panadol Extra, Apadaz, Nalocet, Dvorah, Anacin AF, Bupap, Endocet, Esgic, Excedrin, Excedrin PM, Feverall, Fioricet with Codeine, Legatrin PM, Mapap, Marten-Tab, Norco, Redutemp, Repan, Saleto, Tempra Quicklets, Tencon, Tycolene, Tylenol Gelcap Extra Strength, Tylenol PM, Tylenol with Codeine, Unisom with Pain Relief, Vanquish, Zebutal, Acephen, Vtol, Allzital, Prolate, Combogesic, Exaprin Plus, Contragesic, Relagesic, Ultracet, Excedrin Tension Headache, Percocet, Lorcet, Frenadol, Dologesic, Hycet, Anabar, Ed Flex, By Ache, Excedrin Quick Tab, Comtrex Sore Throat Relief, Excedrin Back & Body, Anacin Advanced Headache Formula, Trezix, Tactinal, Backprin

Analgesic • Non-opioid analgesic / Antipyretic

Premium
Hepatotoxic

Half-life

1-4 hours

Protein Binding

Metabolized By

CYP2E1, CYP1A2, CYP3A4

External

Drugs.com

Mechanism of Action

Inhibits central COX; exact mechanism not fully understood; acts centrally

Indications(5)

Endometrial CancerLupus NephritisOpioid TaperingHematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm

Classification

Drug Class

Analgesic

Subclass

Non-opioid analgesic / Antipyretic

Brand Names

TylenolParacetamolPanadolCalpolLittle FeversBactimicinaPamprin Max FormulaPamprin Multi-SymptomPamprin Cramp FormulaPercogesic Reformulated Jan 2011Premsyn PMSPanadol PMCounterAct PainCapacetNortempAcetadrylRinglPharbetolArthriten Inflammatory PainBackaidCetafenExaprinBackaid IPFLortabPrimlevVerdrocetExcedrin Mild HeadacheExcedrin PM Triple ActionNinjacof AVanatolFioricetSed-MaxPanadol ExtraApadazNalocetDvorahAnacin AFBupapEndocetEsgicExcedrinExcedrin PMFeverallFioricet with CodeineLegatrin PMMapapMarten-TabNorcoRedutempRepanSaletoTempra QuickletsTenconTycoleneTylenol Gelcap Extra StrengthTylenol PMTylenol with CodeineUnisom with Pain ReliefVanquishZebutalAcephenVtolAllzitalProlateCombogesicExaprin PlusContragesicRelagesicUltracetExcedrin Tension HeadachePercocetLorcetFrenadolDologesicHycetAnabarEd FlexBy AcheExcedrin Quick TabComtrex Sore Throat ReliefExcedrin Back & BodyAnacin Advanced Headache FormulaTrezixTactinalBackprin

Key Properties

Half-life

1-4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Acetaminophen (Paracetamol) Drug Profile | PharmaGraphX