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  3. /Metformin

Metformin

Glucophage, Glucophage XR, Fortamet, Kazano, Jentadueto, Kombiglyze, Janumet, Invokamet, Xigduo, Synjardy, Segluromet, Trijardy, Zituvimet, Riomet, Actoplus Met, Glumetza

Antidiabetic • Biguanide

Premium

Half-life

6.2 h

Protein Binding

Metabolized By

CYP3A4, CYP2C8, CYP2C9

External

Drugs.com

Mechanism of Action

Decreases hepatic gluconeogenesis and increases insulin sensitivity

Indications(3)

Type 2 diabetes mellitus — first-linePolycystic ovary syndrome (PCOS)Prevention of type 2 diabetes in high-risk patients

Classification

Drug Class

Antidiabetic

Subclass

Biguanide

Brand Names

GlucophageGlucophage XRFortametKazanoJentaduetoKombiglyzeJanumetInvokametXigduoSynjardySeglurometTrijardyZituvimetRiometActoplus MetGlumetza

Key Properties

Half-life

6.2 h

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Metformin Drug Profile | PharmaGraphX