Oxycodone

OxyContin, Percocet (with APAP), Primlev, Oxaydo, Xtampza, Roxybond, Nalocet, Endocet, Roxicodone, Prolate, Percocet

Opioid • Semi-synthetic opioid agonist

Premium

NTICNS Depressant

Half-life

3-5 hours

Protein Binding

45%

Metabolized By

CYP3A4, CYP2D6

External

Drugs.com

Boxed warning

Addiction/abuse/misuse
Respiratory depression
Neonatal withdrawal
CYP3A4 interactions

Clinical alerts

Boxed warning

4 boxed warnings

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Agonist at mu-opioid receptors in the CNS

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Carpal Tunnel Syndrome
·Acute Pain
·Post Operative Pain
·Supracondylar Humerus Fracture
·Post-Mastectomy Neuropathic Pain Syndrome

Interactions

2 curated · 2 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
alprazolam	contraindicated	LIFE-THREATENING respiratory depression, profound sedation, coma, and death.
rifampicin	major	Near-complete loss of opioid analgesia; risk of uncontrolled pain and potential opioid withdrawal in dependent patients.

Common adverse effects

Constipation
Nausea
Sedation
Respiratory depression

Food, alcohol & herbal

Food

Grapefruit may increase levels

Alcohol · major

LIFE-THREATENING respiratory depression. CONTRAINDICATED with alcohol.

Herbal

Valerian (moderate) — Additive CNS depression

Pharmacokinetics

Half-life: 3-5 hours
Protein binding: 45%
Metabolised by: CYP3A4, CYP2D6

Pregnancy & lactation

Not recorded for Oxycodone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Oxycodone

OxyContin, Percocet (with APAP), Primlev, Oxaydo, Xtampza, Roxybond, Nalocet, Endocet, Roxicodone, Prolate, Percocet

Opioid • Semi-synthetic opioid agonist

Premium

NTICNS Depressant

Half-life

3-5 hours

Protein Binding

45%

Metabolized By

CYP3A4, CYP2D6

External

Drugs.com

Boxed warning

Addiction/abuse/misuse
Respiratory depression
Neonatal withdrawal
CYP3A4 interactions

Clinical alerts

Boxed warning

4 boxed warnings

Narrow therapeutic index

Small dose changes can cause toxicity or loss of effect

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Agonist at mu-opioid receptors in the CNS

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Carpal Tunnel Syndrome
·Acute Pain
·Post Operative Pain
·Supracondylar Humerus Fracture
·Post-Mastectomy Neuropathic Pain Syndrome

Interactions

2 curated · 2 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
alprazolam	contraindicated	LIFE-THREATENING respiratory depression, profound sedation, coma, and death.
rifampicin	major	Near-complete loss of opioid analgesia; risk of uncontrolled pain and potential opioid withdrawal in dependent patients.

Common adverse effects

Constipation
Nausea
Sedation
Respiratory depression

Food, alcohol & herbal

Food

Grapefruit may increase levels

Alcohol · major

LIFE-THREATENING respiratory depression. CONTRAINDICATED with alcohol.

Herbal

Valerian (moderate) — Additive CNS depression

Pharmacokinetics

Half-life: 3-5 hours
Protein binding: 45%
Metabolised by: CYP3A4, CYP2D6

Pregnancy & lactation

Not recorded for Oxycodone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Oxycodone Drug Profile | PharmaGraphX