Oxycodone

OxyContin, Percocet (with APAP)

Opioid • Semi-synthetic opioid agonist

NTICNS Depressant

Half-life

3-5 hours

Protein Binding

45%

Metabolized By

CYP3A4, CYP2D6

External

Agonist at mu-opioid receptors in the CNS

Drug Class

Opioid

Subclass

Semi-synthetic opioid agonist

OxyContinPercocet (with APAP)

Half-life

3-5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

45%

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses