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  3. /Digoxin

Digoxin

Lanoxin, Digox, Digitek

Cardiac glycoside • Cardiac glycoside

Premium
NTIQT Risk

Half-life

36-48 hours

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Inhibits Na+/K+-ATPase, increasing intracellular calcium and cardiac contractility

Indications(3)

Atrial fibrillation — ventricular rate controlAtrial flutterHeart failure with reduced ejection fraction (HFrEF)

Classification

Drug Class

Cardiac glycoside

Subclass

Cardiac glycoside

Brand Names

LanoxinDigoxDigitek

Key Properties

Half-life

36-48 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Digoxin Drug Profile | PharmaGraphX