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Cordarone, Pacerone, Nexterone
Antiarrhythmic • Class III antiarrhythmic
PremiumHalf-life
40-55 days
Protein Binding
96%
Metabolized By
CYP3A4, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2A6, CYP2B6
External
Drugs.comBlocks potassium, sodium, and calcium channels; also has beta-blocking properties
From the drug index — may include conditions studied rather than approved indications
Typical adult starting point — always confirm against local guidelines
6 curated · 5 major or contraindicated · select a row for management
| Interacting drug | Severity | Effect |
|---|---|---|
| azithromycin | major | Additive QT prolongation, increased risk of Torsades de Pointes |
| digoxin | major | Digoxin toxicity with cardiac arrhythmias. |
| haloperidol | major | High risk of Torsades de Pointes |
| simvastatin | major | Increased myopathy/rhabdomyolysis risk |
| warfarin | major | Warfarin effect may increase by 30-50%. Onset may be delayed 1-2 weeks. |
| sildenafil | moderate | Excessive hypotension and QT prolongation risk. |
Additive hepatotoxicity
Published parameters · Textbook: Rowland & Tozer, Clinical Pharmacokinetics 5th Ed
Not recorded for Amiodarone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Assembled from: drug index, curated drug database, curated interaction pairs, published PK literature.
