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  3. /Amiodarone

Amiodarone

Cordarone, Pacerone, Nexterone

Antiarrhythmic • Class III antiarrhythmic

Premium
NTIQT RiskHepatotoxic

Half-life

1392 h

Protein Binding

Metabolized By

CYP3A4, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2A6, CYP2B6

External

Drugs.com

Mechanism of Action

Blocks potassium, sodium, and calcium channels; also has beta-blocking properties

Indications(4)

Ventricular tachycardiaVentricular fibrillationAtrial fibrillation — rate and rhythm controlAtrial flutter

Classification

Drug Class

Antiarrhythmic

Subclass

Class III antiarrhythmic

Brand Names

CordaronePaceroneNexterone

Key Properties

Half-life

1392 h

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Amiodarone Drug Profile | PharmaGraphX