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  3. /Itraconazole

Itraconazole

Sporanox, Onmel, Tolsura

Antifungal • Triazole antifungal

Premium
QT RiskHepatotoxic

Half-life

21 hours (64 hours with chronic dosing)

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

Inhibits fungal CYP450-dependent 14-alpha-demethylase, blocking ergosterol synthesis

Indications(5)

Fallopian Tube CancerOvarian CancerPrimary PeritonealHealthyObesity &Amp; Overweight

Classification

Drug Class

Antifungal

Subclass

Triazole antifungal

Brand Names

SporanoxOnmelTolsura

Key Properties

Half-life

21 hours (64 hours with chronic dosing)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Itraconazole Drug Profile | PharmaGraphX