Itraconazole

Sporanox, Onmel, Tolsura

Antifungal • Triazole antifungal

Premium

QT RiskHepatotoxic

Half-life

21 hours (64 hours with chronic dosing)

Protein Binding

99.8%

Metabolized By

CYP3A4

External

Drugs.com

Boxed warning

Heart failure — negative inotropic effect
Hepatotoxicity
Drug interactions

Clinical alerts

Boxed warning

3 boxed warnings

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Hepatotoxic

Monitor liver function

Mechanism of action

Inhibits fungal CYP450-dependent 14-alpha-demethylase, blocking ergosterol synthesis

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Fallopian Tube Cancer
·Ovarian Cancer
·Primary Peritoneal
·Healthy
·Obesity &Amp; Overweight

Interactions

1 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
simvastatin	contraindicated	Major increase in statin levels with high rhabdomyolysis risk

Common adverse effects

Nausea
Diarrhea
Abdominal pain
Headache
Rash

Food, alcohol & herbal

Food

Capsules: take with food; Solution: take on empty stomach

Alcohol · moderate

Additive hepatotoxicity

Herbal

St. John's Wort (major) — Dramatically reduces itraconazole levels

Pharmacokinetics

Half-life: 21 hours (64 hours with chronic dosing)
Protein binding: 99.8%
Metabolised by: CYP3A4
Inhibits: CYP3A4, P-gp

Pregnancy & lactation

Not recorded for Itraconazole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Itraconazole

Sporanox, Onmel, Tolsura

Antifungal • Triazole antifungal

Premium

QT RiskHepatotoxic

Half-life

21 hours (64 hours with chronic dosing)

Protein Binding

99.8%

Metabolized By

CYP3A4

External

Drugs.com

Boxed warning

Heart failure — negative inotropic effect
Hepatotoxicity
Drug interactions

Clinical alerts

Boxed warning

3 boxed warnings

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Hepatotoxic

Monitor liver function

Mechanism of action

Inhibits fungal CYP450-dependent 14-alpha-demethylase, blocking ergosterol synthesis

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Fallopian Tube Cancer
·Ovarian Cancer
·Primary Peritoneal
·Healthy
·Obesity &Amp; Overweight

Interactions

1 curated · 1 major or contraindicated · select a row for management

Interacting drug	Severity	Effect
simvastatin	contraindicated	Major increase in statin levels with high rhabdomyolysis risk

Common adverse effects

Nausea
Diarrhea
Abdominal pain
Headache
Rash

Food, alcohol & herbal

Food

Capsules: take with food; Solution: take on empty stomach

Alcohol · moderate

Additive hepatotoxicity

Herbal

St. John's Wort (major) — Dramatically reduces itraconazole levels

Pharmacokinetics

Half-life: 21 hours (64 hours with chronic dosing)
Protein binding: 99.8%
Metabolised by: CYP3A4
Inhibits: CYP3A4, P-gp

Pregnancy & lactation

Not recorded for Itraconazole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database, curated interaction pairs.

Not a substitute for clinical judgement

Itraconazole Drug Profile | PharmaGraphX