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Sporanox, Onmel
Antifungal • Triazole antifungal
Half-life
21 hours (64 hours with chronic dosing)
Protein Binding
99.8%
Metabolized By
CYP3A4
External
Drugs.comInhibits fungal CYP450-dependent 14-alpha-demethylase, blocking ergosterol synthesis
Drug Class
Antifungal
Subclass
Triazole antifungal
Half-life
21 hours (64 hours with chronic dosing)
Time for plasma concentration to decrease by 50%
Protein Binding
99.8%
Fraction bound to plasma proteins
Therapeutic Index
Wide
Margin between therapeutic and toxic doses