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  3. /Verapamil

Verapamil

Calan, Calan SR, Verelan, Isoptin

Calcium channel blocker • Non-dihydropyridine CCB

Premium
QT Risk

Half-life

6-8 hours (single dose); 12 hours (chronic)

Protein Binding

Metabolized By

CYP3A4, CYP1A2, CYP2C8

External

Drugs.com

Mechanism of Action

Blocks L-type calcium channels with prominent cardiac effects

Indications(5)

Multi Drug Resistant OrganismsMultidrug-Resistant Bacterial Infections in Cancer PatientsAntibiotic ResistanceEfflux Pump-Mediated ResistanceHospital-Acquired Bacterial Infections

Classification

Drug Class

Calcium channel blocker

Subclass

Non-dihydropyridine CCB

Brand Names

CalanCalan SRVerelanIsoptin

Key Properties

Half-life

6-8 hours (single dose); 12 hours (chronic)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Verapamil Drug Profile | PharmaGraphX