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Calan, Calan SR, Verelan, Isoptin
Calcium channel blocker • Non-dihydropyridine CCB
Half-life
6-8 hours (single dose); 12 hours (chronic)
Protein Binding
90%
Metabolized By
CYP3A4, CYP1A2, CYP2C8
External
Drugs.comBlocks L-type calcium channels with prominent cardiac effects
Drug Class
Calcium channel blocker
Subclass
Non-dihydropyridine CCB
Half-life
6-8 hours (single dose); 12 hours (chronic)
Time for plasma concentration to decrease by 50%
Protein Binding
90%
Fraction bound to plasma proteins
Therapeutic Index
Wide
Margin between therapeutic and toxic doses