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  3. /Ciprofloxacin

Ciprofloxacin

Cipro, Cipro XR, Otiprio, Otovel, Ciloxan, Cipro HC, Ciprodex, Proquin, Cetraxal

Antibiotic • Fluoroquinolone

Premium
QT RiskNephrotoxic

Half-life

4 hours

Protein Binding

Metabolized By

CYP1A2

External

Drugs.com

Mechanism of Action

Inhibits bacterial DNA gyrase and topoisomerase IV

Indications(5)

Urinary Tract Infections (UTIs)Catheter-Associated Urinary Tract Infections (CAUTIs)Biofilm Formation by Uropathogenic Escherichia Coli (UPEC)Acute Uncomplicated DiverticulitisDietary Modification

Classification

Drug Class

Antibiotic

Subclass

Fluoroquinolone

Brand Names

CiproCipro XROtiprioOtovelCiloxanCipro HCCiprodexProquinCetraxal

Key Properties

Half-life

4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ciprofloxacin Drug Profile | PharmaGraphX