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Aldactone, Aldactazide, Carospir, Cardalis
Diuretic • Potassium-sparing diuretic / Aldosterone antagonist
PremiumHalf-life
1.4 hours (active metabolites longer)
Protein Binding
>90%
Metabolized By
CYP3A4, CYP2C8
External
Drugs.comCompetitive antagonist of aldosterone at the mineralocorticoid receptor
From the drug index — may include conditions studied rather than approved indications
1 curated · 1 major or contraindicated · select a row for management
| Interacting drug | Severity | Effect |
|---|---|---|
| lisinopril | major | Hyperkalemia risk, especially in renal impairment or diabetes |
Additive hypotension and orthostatic effects
Not recorded for Spironolactone. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Assembled from: drug index, curated drug database, curated interaction pairs.
