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  3. /Lithium

Lithium

Lithobid, Eskalith

Mood stabilizer • Alkali metal salt

Premium
NTIQT RiskCNS DepressantNephrotoxic

Half-life

18-36 hours

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Modulates neurotransmitter release, intracellular signaling cascades, and gene expression

Indications(4)

Bipolar disorder — acute manic episodesBipolar disorder — maintenance (relapse prevention)Augmentation in treatment-resistant depressionCluster headache prophylaxis

Classification

Drug Class

Mood stabilizer

Subclass

Alkali metal salt

Brand Names

LithobidEskalith

Key Properties

Half-life

18-36 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Lithium Drug Profile | PharmaGraphX