Acyclovir

Zovirax

Antiviral • Nucleoside analog

Nephrotoxic

Half-life

2.5-3.3 hours

Protein Binding

9-33%

Metabolized By

N/A

External

Selectively phosphorylated by viral thymidine kinase, then inhibits viral DNA polymerase

Drug Class

Antiviral

Subclass

Nucleoside analog

Zovirax

Half-life

2.5-3.3 hours

Time for plasma concentration to decrease by 50%

Protein Binding

9-33%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses