Vortioxetine Drug Profile

Boxed warning

Suicidality in children, adolescents, and young adults

Clinical alerts

Boxed warning

1 boxed warning

Bleeding risk

Additive with other antithrombotics and NSAIDs

Serotonergic

Serotonin syndrome risk when combined with other serotonergic drugs

Mechanism of action

SERT inhibitor + 5-HT1A agonist + 5-HT1B partial agonist + 5-HT3/5-HT7 antagonist

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Major Depressive Disorder
·Fronto-temporal Dementia
·Fronto-temporal Lobar Dementia
·Frontotemporal Degeneration
·Frontotemporal Dementia (FTD)

Interactions

No curated interaction pairs are recorded for Vortioxetine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Constipation
Vomiting
Dizziness

Food, alcohol & herbal

Alcohol · moderate

May worsen cognitive impairment

Herbal

St. John's Wort (major) — Risk of serotonin syndrome

Pharmacokinetics

Half-life: 66 hours
Protein binding: 98%
Metabolised by: CYP2D6, CYP3A4

Pregnancy & lactation

Not recorded for Vortioxetine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.