Vancomycin

Inhibits cell wall synthesis by binding to D-Ala-D-Ala terminus of peptidoglycan precursors

• ·Advanced Non Small Cell Lung Cancer
• ·Surgical Site Infection
• ·Clostridioides Difficile Infection
• ·Blood-Brain Barrier
• ·Bacterial Meningitis

Typical dose

[object Object] mg every 12 h

Intravenous

Loading dose

[object Object] mg

Therapeutic range

10–20 mg/L

Trough

Peak range

25–40 mg/L

Steady state

~24-30 hours (4-5 half-lives)

Re-check

Every 48-72h until stable, then weekly

• Trough: 30 min before next dose
• Peak: 1-2 h after infusion end

No curated interaction pairs are recorded for Vancomycin. This is not a statement that none exist — check a full interaction reference before combining.

• Red man syndrome (infusion-related)
• Nephrotoxicity
• Ototoxicity
• Phlebitis

Half-life

4-6 hours

Protein binding

55%

Clearance

4 L/h

adult patients with normal renal function

Volume of distribution

30 L

Renally eliminated

90%

Dose review in renal impairment

Model

2-compartment

Not recorded for Vancomycin. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.