Valproic Acid

Depakene, Depakote, Depakote ER

Antiepileptic • Multiple mechanisms

NTIBleedingCNS DepressantHepatotoxic

Half-life

9-16 hours

Protein Binding

80-90%

Metabolized By

CYP2C9, CYP2C19, UGT

External

Increases GABA levels, blocks voltage-gated sodium channels, inhibits histone deacetylase

Drug Class

Antiepileptic

Subclass

Multiple mechanisms

DepakeneDepakoteDepakote ER

Half-life

9-16 hours

Time for plasma concentration to decrease by 50%

Protein Binding

80-90%

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses