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  3. /Valproic Acid

Valproic Acid

Depakene, Depakote, Depakote ER

Antiepileptic • Multiple mechanisms

Premium
NTIBleedingCNS DepressantHepatotoxic

Half-life

9-16 hours

Protein Binding

Metabolized By

CYP2C9, CYP2C19, UGT

External

Drugs.com

Mechanism of Action

Increases GABA levels, blocks voltage-gated sodium channels, inhibits histone deacetylase

Indications(5)

ManiaBipolar DisorderTemporomandibular Joint Internal Derangement (ADWR)Bipolar Disorder Type I With ManiaCiliary Body and Choroid Melanoma, Medium/Large Size

Classification

Drug Class

Antiepileptic

Subclass

Multiple mechanisms

Brand Names

DepakeneDepakoteDepakote ER

Key Properties

Half-life

9-16 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Valproic Acid Drug Profile | PharmaGraphX