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  3. /Trastuzumab

Trastuzumab

Herceptin, Herzuma, Ogivri, KADCYLA, Herceptin Hylecta, Kanjinti, Enhertu, Trazimera, Ontruzant, Phesgo, Hercessi

Biologic • Anti-HER2 monoclonal antibody

Premium

Half-life

28.5 days

Protein Binding

Metabolized By

Proteolytic degradation

External

Drugs.com

Mechanism of Action

Humanized antibody targeting HER2/neu receptor, inhibiting proliferation and inducing ADCC

Classification

Drug Class

Biologic

Subclass

Anti-HER2 monoclonal antibody

Brand Names

HerceptinHerzumaOgivriKADCYLAHerceptin HylectaKanjintiEnhertuTrazimeraOntruzantPhesgoHercessi

Key Properties

Half-life

28.5 days

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Trastuzumab Drug Profile | PharmaGraphX