Topiramate

Topamax, Trokendi XR, Qudexy XR

Antiepileptic • Sulfamate-substituted monosaccharide

CNS DepressantNephrotoxic

Half-life

21 hours

Protein Binding

15-41%

Metabolized By

CYP3A4

External

Multiple: blocks Na+ channels, enhances GABA, inhibits glutamate, weak carbonic anhydrase inhibitor

Drug Class

Antiepileptic

Subclass

Sulfamate-substituted monosaccharide

TopamaxTrokendi XRQudexy XR

Half-life

21 hours

Time for plasma concentration to decrease by 50%

Protein Binding

15-41%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses