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  3. /Tizanidine

Tizanidine

Zanaflex, Ontralfy

Muscle relaxant • Alpha-2 adrenergic agonist

Premium
QT RiskCNS DepressantHepatotoxic

Half-life

2.5 hours

Protein Binding

Metabolized By

CYP1A2

External

Drugs.com

Mechanism of Action

Activates alpha-2 adrenergic receptors, reducing spinal motor neuron excitability

Indications(5)

Drug-Drug InteractionShoulder ArthropathyShoulder PainFibromyalgiaPregabalin

Classification

Drug Class

Muscle relaxant

Subclass

Alpha-2 adrenergic agonist

Brand Names

ZanaflexOntralfy

Key Properties

Half-life

2.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Tizanidine Drug Profile | PharmaGraphX