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Tizanidine

Zanaflex, Ontralfy

Muscle relaxant • Alpha-2 adrenergic agonist

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QT RiskCNS DepressantHepatotoxic

Half-life

2.5 hours

Protein Binding

30%

Metabolized By

CYP1A2

External

Drugs.com

Clinical alerts

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Hepatotoxic

Monitor liver function

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Activates alpha-2 adrenergic receptors, reducing spinal motor neuron excitability

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Drug-Drug Interaction
·Shoulder Arthropathy
·Shoulder Pain
·Fibromyalgia
·Pregabalin

Interactions

No curated interaction pairs are recorded for Tizanidine. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Dry mouth
Somnolence
Dizziness
Hypotension
Weakness

Food, alcohol & herbal

Food

Food increases peak concentration; take consistently

Alcohol · major

Severe CNS depression

Pharmacokinetics

Half-life: 2.5 hours
Protein binding: 30%
Metabolised by: CYP1A2

Pregnancy & lactation

Not recorded for Tizanidine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement