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  3. /Terbinafine

Terbinafine

Lamisil, Silka Cream, Simplera, Duotic, Osurnia, Klentz

Antifungal • Allylamine antifungal

Premium
Hepatotoxic

Half-life

36 hours (effective tissue half-life: 200-400 hours)

Protein Binding

Metabolized By

CYP2C9, CYP3A4, CYP2C8, CYP1A2, CYP2C19

External

Drugs.com

Mechanism of Action

Inhibits squalene epoxidase, blocking ergosterol synthesis

Indications(5)

Recurrent Prostate CancerOnychomycosis of ToenailTinea CapitisFungal ResistanceOtomycosis

Classification

Drug Class

Antifungal

Subclass

Allylamine antifungal

Brand Names

LamisilSilka CreamSimpleraDuoticOsurniaKlentz

Key Properties

Half-life

36 hours (effective tissue half-life: 200-400 hours)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Terbinafine Drug Profile | PharmaGraphX