Tacrolimus

Prograf, Astagraf XL, Envarsus XR

Immunosuppressant • Calcineurin inhibitor

NTIQT RiskNephrotoxic

Half-life

11-16 hours

Protein Binding

99%

Metabolized By

CYP3A4, CYP3A5

External

Binds to FKBP-12, inhibiting calcineurin and preventing T-cell activation

Drug Class

Immunosuppressant

Subclass

Calcineurin inhibitor

PrografAstagraf XLEnvarsus XR

Half-life

11-16 hours

Time for plasma concentration to decrease by 50%

Protein Binding

99%

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses