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  3. /Sumatriptan

Sumatriptan

Imitrex, Onzetra, Tosymra, Zembrace, Treximet

Antimigraine • Triptan (5-HT1B/1D agonist)

Premium
Serotoninergic

Half-life

2-2.5 hours

Protein Binding

Metabolized By

MAO-A

External

Drugs.com

Mechanism of Action

Agonist at 5-HT1B/1D receptors, causing cranial vasoconstriction and inhibiting trigeminal nociception

Classification

Drug Class

Antimigraine

Subclass

Triptan (5-HT1B/1D agonist)

Brand Names

ImitrexOnzetraTosymraZembraceTreximet

Key Properties

Half-life

2-2.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Sumatriptan Drug Profile | PharmaGraphX