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  3. /Sulfasalazine

Sulfasalazine

Azulfidine, Azulfidine EN-tabs

DMARD • Aminosalicylate / Sulfonamide

Premium
HepatotoxicNephrotoxic

Half-life

5-10 hours

Protein Binding

Metabolized By

Intestinal bacteria, NAT2

External

Drugs.com

Mechanism of Action

Cleaved by gut bacteria to 5-ASA and sulfapyridine; anti-inflammatory and immunomodulatory

Indications(5)

Rheumatoid ArthritisPrimary Sclerosing CholangitisAutoimmune Rheumatic DiseasesInflammatory ArthritisDiabetes (DM)

Classification

Drug Class

DMARD

Subclass

Aminosalicylate / Sulfonamide

Brand Names

AzulfidineAzulfidine EN-tabs

Key Properties

Half-life

5-10 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Sulfasalazine Drug Profile | PharmaGraphX