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  3. /Solifenacin

Solifenacin

Vesicare

Urinary antispasmodic • Antimuscarinic

Premium
QT Risk

Half-life

45-68 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

M3 muscarinic receptor antagonist with bladder selectivity

Indications(5)

Overactive Bladder (OAB)Urge IncontinenceHot FlashesBreast CancerOveractive Bladder

Classification

Drug Class

Urinary antispasmodic

Subclass

Antimuscarinic

Brand Names

Vesicare

Key Properties

Half-life

45-68 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Solifenacin Drug Profile | PharmaGraphX