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Sofosbuvir

Sovaldi, Harvoni, Epclusa, Vosevi

Uncategorized

Standard

Half-life

0.4 hours (parent); 27 hours (active metabolite)

Protein Binding

61-65%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Risk of HBV reactivation in co-infected patients

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Nucleotide analog inhibiting HCV NS5B RNA-dependent RNA polymerase

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Diabetes Mellitus
·Hepatitis C, Chronic
·Cardiovascular Diseases
·End Stage Renal Disease
·HEPATITIS C (HCV)

Interactions

No curated interaction pairs are recorded for Sofosbuvir. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Fatigue
Headache
Nausea
Insomnia

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Herbal

St. John's Wort (major) — Significantly reduces sofosbuvir levels via P-gp induction

Pharmacokinetics

Half-life: 0.4 hours (parent); 27 hours (active metabolite)
Protein binding: 61-65%

Pregnancy & lactation

Not recorded for Sofosbuvir. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement

Sofosbuvir

Sovaldi, Harvoni, Epclusa, Vosevi

Uncategorized

Standard

Half-life

0.4 hours (parent); 27 hours (active metabolite)

Protein Binding

61-65%

Metabolized By

N/A

External

Drugs.com

Boxed warning

Risk of HBV reactivation in co-infected patients

Clinical alerts

Boxed warning

1 boxed warning

Mechanism of action

Nucleotide analog inhibiting HCV NS5B RNA-dependent RNA polymerase

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Diabetes Mellitus
·Hepatitis C, Chronic
·Cardiovascular Diseases
·End Stage Renal Disease
·HEPATITIS C (HCV)

Interactions

No curated interaction pairs are recorded for Sofosbuvir. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Fatigue
Headache
Nausea
Insomnia

Food, alcohol & herbal

Alcohol · minor

No significant interaction

Herbal

St. John's Wort (major) — Significantly reduces sofosbuvir levels via P-gp induction

Pharmacokinetics

Half-life: 0.4 hours (parent); 27 hours (active metabolite)
Protein binding: 61-65%

Pregnancy & lactation

Not recorded for Sofosbuvir. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement