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  3. /Sitagliptin

Sitagliptin

Januvia, Janumet, Steglujan, Zituvio, Zituvimet, Brynovin

Antidiabetic • DPP-4 inhibitor

Premium

Half-life

12.4 hours

Protein Binding

Metabolized By

CYP3A4, CYP2C8

External

Drugs.com

Mechanism of Action

Inhibits dipeptidyl peptidase-4, increasing incretin levels

Indications(5)

Healthy VolunteersType 2 DiabetesHeart FailureType 2 Diabetes (Adult Onset)Type 2 Diabetes Mellitus

Classification

Drug Class

Antidiabetic

Subclass

DPP-4 inhibitor

Brand Names

JanuviaJanumetSteglujanZituvioZituvimetBrynovin

Key Properties

Half-life

12.4 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Sitagliptin Drug Profile | PharmaGraphX