Press Esc to close
Entresto
Heart failure • Angiotensin receptor-neprilysin inhibitor (ARNI)
Half-life
~12 hours (sacubitrilat); 6 hours (valsartan)
Protein Binding
94-97%
Metabolized By
CYP3A4, CYP2C9
External
Drugs.comSacubitril inhibits neprilysin (enhances natriuretic peptides); valsartan blocks AT1 receptor
No curated interaction pairs are recorded for Sacubitril/Valsartan. This is not a statement that none exist — check a full interaction reference before combining.
Additive hypotension
Assembled from: drug index, curated drug database.
