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Roflumilast

Daliresp, Zoryve

Uncategorized

Standard

Half-life

17 hours (active metabolite: 30 hours)

Protein Binding

99%

Metabolized By

N/A

External

Drugs.com

Mechanism of action

Selectively inhibits phosphodiesterase-4, reducing inflammation in COPD

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Healthy Volunteers
·Acute Exacerbation of Chronic Obstructive Pulmonary Disease
·Influenza, Human
·Virus Diseases
·Chronic Obstructive Pulmonary Disease Severe

Interactions

No curated interaction pairs are recorded for Roflumilast. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Diarrhea
Weight loss
Nausea
Headache
Insomnia

Food, alcohol & herbal

Alcohol · moderate

May increase psychiatric adverse effects

Pharmacokinetics

Half-life: 17 hours (active metabolite: 30 hours)
Protein binding: 99%
Metabolised by: CYP3A4, CYP1A2

Pregnancy & lactation

Not recorded for Roflumilast. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement