Ramelteon

Rozerem

Hypnotic • Melatonin receptor agonist

CNS DepressantHepatotoxic

Half-life

1-2.6 hours

Protein Binding

82%

Metabolized By

CYP1A2, CYP2C9, CYP3A4

External

Agonist at MT1 and MT2 melatonin receptors in suprachiasmatic nucleus

Drug Class

Hypnotic

Subclass

Melatonin receptor agonist

Rozerem

Half-life

1-2.6 hours

Time for plasma concentration to decrease by 50%

Protein Binding

82%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses