Severe hepatotoxicity including hepatic failure, liver transplant, and death
Clinical alerts
Boxed warning
1 boxed warning
Hepatotoxic
Monitor liver function
Mechanism of action
Inhibits thyroid peroxidase and peripheral conversion of T4 to T3
Recorded indications
From the drug index — may include conditions studied rather than approved indications
·Digestive Cancers
·Breast Cancer
·Gynecologic Cancer
·Lung Cancer
·Nose Cancer
Interactions
No curated interaction pairs are recorded for Propylthiouracil. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Rash
Arthralgias
GI upset
Agranulocytosis (rare)
Food, alcohol & herbal
Alcohol · moderate
Additive hepatotoxicity
Pharmacokinetics
Half-life
1-2 hours
Protein binding
80%
Pregnancy & lactation
Pregnancy category
D
Sources
Assembled from: drug index, curated drug database.
