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Pramipexole

Mirapex, Mirapex ER

Antiparkinson • Dopamine agonist (D2/D3 preferring)

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CNS Depressant

Half-life

8-12 hours

Protein Binding

15%

Metabolized By

Minimal metabolism

External

Drugs.com

Clinical alerts

CNS depressant

Additive sedation with other CNS depressants and alcohol

Mechanism of action

Directly stimulates D2 and D3 dopamine receptors in the striatum

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Major Depressive Disorder
·Mild Neurocognitive Disorder
·HIV
·Adrenoleukodystrophy
·Restless Legs Syndrome

Interactions

No curated interaction pairs are recorded for Pramipexole. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Dizziness
Somnolence
Hallucinations
Impulse control disorders

Food, alcohol & herbal

Food

May be taken with or without food

Alcohol · moderate

Additive sedation

Pharmacokinetics

Half-life: 8-12 hours
Protein binding: 15%
Metabolised by: Minimal metabolism

Pregnancy & lactation

Not recorded for Pramipexole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement