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Posaconazole

Posatex, Mometamax Single, Noxafil

Uncategorized

Standard

Half-life

35 hours

Protein Binding

98%

Metabolized By

N/A

External

Drugs.com

Clinical alerts

QT prolongation

Avoid combining with other QT-prolonging agents; check electrolytes

Hepatotoxic

Monitor liver function

Mechanism of action

Inhibits fungal CYP51, disrupting ergosterol synthesis; broadest spectrum triazole

Recorded indications

From the drug index — may include conditions studied rather than approved indications

·Leukemia, Myeloid, Acute
·Leukemia, Lymphocytic, Acute
·Multiple Myeloma
·Myelodysplastic Syndromes
·Acute Myeloid Leukemia

Interactions

No curated interaction pairs are recorded for Posaconazole. This is not a statement that none exist — check a full interaction reference before combining.

Common adverse effects

Nausea
Diarrhea
Headache
Elevated LFTs

Food, alcohol & herbal

Food

Oral suspension: take with full meal or nutritional supplement for absorption

Alcohol · moderate

Additive hepatotoxicity

Pharmacokinetics

Half-life: 35 hours
Protein binding: 98%
Inhibits: CYP3A4

Pregnancy & lactation

Not recorded for Posaconazole. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.

Sources

Assembled from: drug index, curated drug database.

Not a substitute for clinical judgement