Small dose changes can cause toxicity or loss of effect
Hepatotoxic
Monitor liver function
Serotonergic
Serotonin syndrome risk when combined with other serotonergic drugs
Mechanism of action
Irreversibly inhibits MAO-A and MAO-B
Interactions
No curated interaction pairs are recorded for Phenelzine. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Orthostatic hypotension
Weight gain
Insomnia
Edema
Food, alcohol & herbal
Food
Strict tyramine-free diet required
Alcohol · major
Hypertensive crisis risk
Herbal
St. John's Wort (major) — Fatal serotonin syndrome risk
Pharmacokinetics
Half-life
11-12 hours
Protein binding
N/A
Pregnancy & lactation
Not recorded for Phenelzine. Absence here means this database does not hold a category — not that the drug is safe in pregnancy or breastfeeding.
Sources
Assembled from: drug index, curated drug database.
