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  3. /Ondansetron

Ondansetron

Zofran, Zofran ODT, Zuplenz

Antiemetic • 5-HT3 receptor antagonist

Premium
QT RiskSerotoninergic

Half-life

3-6 hours

Protein Binding

Metabolized By

CYP3A4, CYP1A2, CYP2D6

External

Drugs.com

Mechanism of Action

Selectively blocks serotonin 5-HT3 receptors in CTZ and vagal afferents

Indications(5)

Breast CancerAllergyNausea and Vomiting Chemotherapy-InducedNausea Post ChemotherapyPostoperative Nausea and Vomiting

Classification

Drug Class

Antiemetic

Subclass

5-HT3 receptor antagonist

Brand Names

ZofranZofran ODTZuplenz

Key Properties

Half-life

3-6 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Ondansetron Drug Profile | PharmaGraphX