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  3. /Olanzapine

Olanzapine

Zyprexa, Zyprexa Zydis, Lybalvi, Symbyax

Antipsychotic • Second-generation (atypical) antipsychotic

Premium
QT RiskCNS Depressant

Half-life

30 h

Protein Binding

Metabolized By

CYP1A2, CYP2D6

External

Drugs.com

Mechanism of Action

Antagonizes multiple receptors including D2, 5-HT2A, H1, and muscarinic receptors

Indications(5)

Breast CancerInsulin ResistanceMenstrual CycleType 2 DiabetesAntipsychotics

Classification

Drug Class

Antipsychotic

Subclass

Second-generation (atypical) antipsychotic

Brand Names

ZyprexaZyprexa ZydisLybalviSymbyax

Key Properties

Half-life

30 h

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Olanzapine Drug Profile | PharmaGraphX