Olanzapine

Zyprexa, Zyprexa Zydis

Antipsychotic • Second-generation (atypical) antipsychotic

QT RiskCNS Depressant

Half-life

21-54 hours

Protein Binding

93%

Metabolized By

CYP1A2, CYP2D6

External

Antagonizes multiple receptors including D2, 5-HT2A, H1, and muscarinic receptors

Drug Class

Antipsychotic

Subclass

Second-generation (atypical) antipsychotic

ZyprexaZyprexa Zydis

Half-life

21-54 hours

Time for plasma concentration to decrease by 50%

Protein Binding

93%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses