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  3. /Nitroglycerin

Nitroglycerin

Nitrostat, Nitro-Bid, Nitro-Dur, Minitran, Rectiv, Nitrolingual, Gonitro, NitroMist

Nitrate • Organic nitrate vasodilator

Premium

Half-life

1-4 minutes

Protein Binding

Metabolized By

Hepatic first-pass

External

Drugs.com

Mechanism of Action

Releases nitric oxide, causing venodilation and coronary vasodilation

Indications(5)

Achilles Tendon Repairs/ReconstructionsPilon Fracture of TibiaTibial Plateau FractureAnkle Fracture (Bimalleolar Equivalent, Bimalleolar, or Trimalleolar)Calcaneus Fractures

Classification

Drug Class

Nitrate

Subclass

Organic nitrate vasodilator

Brand Names

NitrostatNitro-BidNitro-DurMinitranRectivNitrolingualGonitroNitroMist

Key Properties

Half-life

1-4 minutes

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Nitroglycerin Drug Profile | PharmaGraphX