Nitroglycerin

Nitrostat, Nitro-Bid, Nitro-Dur, Minitran

Nitrate • Organic nitrate vasodilator

Half-life

1-4 minutes

Protein Binding

60%

Metabolized By

Hepatic first-pass

External

Releases nitric oxide, causing venodilation and coronary vasodilation

Drug Class

Nitrate

Subclass

Organic nitrate vasodilator

NitrostatNitro-BidNitro-DurMinitran

Half-life

1-4 minutes

Time for plasma concentration to decrease by 50%

Protein Binding

60%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses