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  3. /Naproxen

Naproxen

Aleve, Naprosyn, Anaprox, Vimovo, Aleve PM, Naprelan, Wal-Proxen, Treximet

NSAID • Propionic acid derivative

Premium
BleedingNephrotoxic

Half-life

12-17 hours

Protein Binding

Metabolized By

CYP2C9, CYP1A2

External

Drugs.com

Mechanism of Action

Non-selective COX-1/COX-2 inhibitor, reducing prostaglandin synthesis

Indications(5)

Acute PainPost Operative PainFrozen ShoulderAdhesive CapsulitisShoulder Pain

Classification

Drug Class

NSAID

Subclass

Propionic acid derivative

Brand Names

AleveNaprosynAnaproxVimovoAleve PMNaprelanWal-ProxenTreximet

Key Properties

Half-life

12-17 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Naproxen Drug Profile | PharmaGraphX