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  3. /Naltrexone

Naltrexone

Revia, Vivitrol, Contrave

Opioid antagonist • Mu-opioid receptor antagonist

Premium
Hepatotoxic

Half-life

4 hours (active metabolite 12 hours)

Protein Binding

Metabolized By

Dihydrodiol dehydrogenase

External

Drugs.com

Mechanism of Action

Competitively antagonizes opioid receptors; reduces alcohol craving through unknown mechanism

Classification

Drug Class

Opioid antagonist

Subclass

Mu-opioid receptor antagonist

Brand Names

ReviaVivitrolContrave

Key Properties

Half-life

4 hours (active metabolite 12 hours)

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Naltrexone Drug Profile | PharmaGraphX