Metoclopramide

Reglan, Metozolv ODT

Antiemetic • Dopamine antagonist / Prokinetic

QT RiskCNS Depressant

Half-life

5-6 hours

Protein Binding

30%

Metabolized By

CYP2D6

External

Blocks dopamine D2 receptors in CTZ; enhances GI motility

Drug Class

Antiemetic

Subclass

Dopamine antagonist / Prokinetic

ReglanMetozolv ODT

Half-life

5-6 hours

Time for plasma concentration to decrease by 50%

Protein Binding

30%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses