Methylphenidate

Ritalin, Concerta, Metadate, Daytrana

CNS Stimulant • Dopamine/norepinephrine reuptake inhibitor

Half-life

2-4 hours (IR); 3.5 hours (ER)

Protein Binding

15%

Metabolized By

CES1A1

External

Blocks dopamine and norepinephrine reuptake, increasing their synaptic concentrations

Drug Class

CNS Stimulant

Subclass

Dopamine/norepinephrine reuptake inhibitor

RitalinConcertaMetadateDaytrana

Half-life

2-4 hours (IR); 3.5 hours (ER)

Time for plasma concentration to decrease by 50%

Protein Binding

15%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses