Additive sedation with other CNS depressants and alcohol
Mechanism of action
Converted to alpha-methylnorepinephrine, stimulating central alpha-2 receptors
Recorded indications
From the drug index — may include conditions studied rather than approved indications
·Autonomic Failure
·Pure Autonomic Failure
·Parkinson Disease
·Multiple System Atrophy
·Dementia With Lewy Bodies
Interactions
No curated interaction pairs are recorded for Methyldopa. This is not a statement that none exist — check a full interaction reference before combining.
Common adverse effects
Drowsiness
Dry mouth
Headache
Positive Coombs test
Food, alcohol & herbal
Alcohol · major
Severe CNS depression
Pharmacokinetics
Half-life
1.5-2 hours
Protein binding
<15%
Pregnancy & lactation
Pregnancy category
B2
Sources
Assembled from: drug index, curated drug database.
