Methotrexate

Trexall, Otrexup, Rasuvo

Antineoplastic • Antimetabolite / DMARD

NTIHepatotoxicNephrotoxic

Half-life

3-10 hours (dose-dependent)

Protein Binding

50%

Metabolized By

N/A

External

Inhibits dihydrofolate reductase, blocking DNA and RNA synthesis

Drug Class

Antineoplastic

Subclass

Antimetabolite / DMARD

TrexallOtrexupRasuvo

Half-life

3-10 hours (dose-dependent)

Time for plasma concentration to decrease by 50%

Protein Binding

50%

Fraction bound to plasma proteins

Therapeutic Index

Narrow

Margin between therapeutic and toxic doses