Memantine

Namenda, Namenda XR

Anti-dementia • NMDA receptor antagonist

CNS Depressant

Half-life

60-80 hours

Protein Binding

45%

Metabolized By

N/A

External

Non-competitive, low-affinity antagonist at NMDA receptors, reducing glutamate excitotoxicity

Drug Class

Anti-dementia

Subclass

NMDA receptor antagonist

NamendaNamenda XR

Half-life

60-80 hours

Time for plasma concentration to decrease by 50%

Protein Binding

45%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses