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  3. /Linezolid

Linezolid

Zyvox

Antibiotic • Oxazolidinone

Premium
Serotoninergic

Half-life

4.5-5.5 hours

Protein Binding

Metabolized By

N/A

External

Drugs.com

Mechanism of Action

Binds to 23S rRNA of 50S ribosomal subunit, inhibiting initiation of translation

Indications(5)

Staphylococcus Aureus Bloodstream Infections (BSI; Bacteremia)Mycobacterium Abscessus Pulmonary DiseaseMycobacterium Abscessus InfectionNon-Tuberculous Mycobacterial (NTM) InfectionsNon-Tuberculous Mycobacteria Pulmonary Disease

Classification

Drug Class

Antibiotic

Subclass

Oxazolidinone

Brand Names

Zyvox

Key Properties

Half-life

4.5-5.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Linezolid Drug Profile | PharmaGraphX