Levodopa-Carbidopa

Sinemet, Sinemet CR, Rytary, Duopa

Antiparkinson • Dopamine precursor + decarboxylase inhibitor

Half-life

1.5 hours

Protein Binding

36%

Metabolized By

DDC, COMT, MAO

External

Levodopa crosses BBB and converts to dopamine; carbidopa prevents peripheral conversion

Drug Class

Antiparkinson

Subclass

Dopamine precursor + decarboxylase inhibitor

SinemetSinemet CRRytaryDuopa

Half-life

1.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

36%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses