Lamotrigine

Lamictal, Lamictal XR

Antiepileptic • Sodium channel blocker

CNS Depressant

Half-life

25-33 hours

Protein Binding

55%

Metabolized By

UGT1A4

External

Stabilizes neuronal membranes by inhibiting voltage-sensitive sodium channels

Drug Class

Antiepileptic

Subclass

Sodium channel blocker

LamictalLamictal XR

Half-life

25-33 hours

Time for plasma concentration to decrease by 50%

Protein Binding

55%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses