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  3. /Isotretinoin

Isotretinoin

Accutane, Absorica, Claravis, Amnesteem, Myorisan, Zenatane, Sotret

Retinoid • Vitamin A derivative

Premium
Hepatotoxic

Half-life

21 hours

Protein Binding

Metabolized By

CYP2C8, CYP3A4, CYP2B6

External

Drugs.com

Mechanism of Action

Normalizes keratinization, reduces sebum production, and has anti-inflammatory effects

Indications(5)

Ganglioneuroblastoma, NodularNeuroblastomaRecurrent NeuroblastomaRefractory NeuroblastomaOligospermia

Classification

Drug Class

Retinoid

Subclass

Vitamin A derivative

Brand Names

AccutaneAbsoricaClaravisAmnesteemMyorisanZenataneSotret

Key Properties

Half-life

21 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Isotretinoin Drug Profile | PharmaGraphX