Indomethacin

Indocin, Tivorbex

NSAID • Indole acetic acid derivative

BleedingCNS DepressantHepatotoxicNephrotoxic

Half-life

4.5 hours

Protein Binding

99%

Metabolized By

CYP2C9, CYP2C19, UGT

External

Potent non-selective COX inhibitor

Drug Class

NSAID

Subclass

Indole acetic acid derivative

IndocinTivorbex

Half-life

4.5 hours

Time for plasma concentration to decrease by 50%

Protein Binding

99%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses