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  3. /Hydroxyzine

Hydroxyzine

Vistaril, Atarax

Antihistamine • First-generation antihistamine / Anxiolytic

Premium
QT RiskCNS Depressant

Half-life

20 hours

Protein Binding

Metabolized By

CYP3A4

External

Drugs.com

Mechanism of Action

H1 antihistamine with anticholinergic and CNS depressant properties

Indications(5)

Multiple SclerosisPapillomavirus InfectionsCervical Intraepithelial NeoplasiaCarcinoma In SituVulvar Neoplasms

Classification

Drug Class

Antihistamine

Subclass

First-generation antihistamine / Anxiolytic

Brand Names

VistarilAtarax

Key Properties

Half-life

20 hours

Time for plasma concentration to decrease by 50%

Protein Binding

—

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses

Not a substitute for clinical judgement
Hydroxyzine Drug Profile | PharmaGraphX