Hydralazine

Apresoline

Vasodilator • Direct arterial vasodilator

Hepatotoxic

Half-life

3-7 hours

Protein Binding

87%

Metabolized By

NAT2 (acetylation)

External

Directly relaxes arterial smooth muscle; exact mechanism unknown

Drug Class

Vasodilator

Subclass

Direct arterial vasodilator

Apresoline

Half-life

3-7 hours

Time for plasma concentration to decrease by 50%

Protein Binding

87%

Fraction bound to plasma proteins

Therapeutic Index

Wide

Margin between therapeutic and toxic doses